Safety and efficacy of early administration of insulin glargine in diabetic ketoacidosis Ashleigh C. Durbin, Emily Green Vance, Jessica V. Rivera University of Alabama Hospital - Birmingham - Birmingham, AL
Background/Purpose: Diabetic ketoacidosis (DKA) accounts for a large number of hospitalizations and intensive care unit (ICU) admissions. Management focuses on the reversal of the underlying cause of acidosis, and goals of therapy include resolution of acidosis, evidenced by closure of the anion gap, and restoration of normal blood glucose levels. Intravenous (IV) fluids, electrolyte repletion, and IV regular insulin remain mainstays of therapy with eventual transition to a basal insulin regimen like glargine. In 2016, an update to the DKA electronic order set was implemented in the emergency department (ED) to include a STAT insulin glargine 0.25 unit/kg subcutaneous dose. The goal of this study was to evaluate the safety and efficacy of early glargine administration by comparing time to anion gap closure (
