Evaluation of immune function, renal function, and glycemic control in HIV/HCV co-infected patients treated with DAA Sonali Patel, Manish Patel, Jane Kriengkauykiat, Lesley Miller Grady Health System - Atlanta, GA
Background/Purpose: There are an estimated 71 million people living with chronic hepatitis C virus (HCV) infection globally, of which approximately 399,000 die yearly mostly from cirrhosis and hepatocellular carcinoma. Patients infected with human immunodeficiency virus (HIV) are at an increased risk of HCV infection and HIV/HCV co-infection presents a particular challenge for management. In addition, extrahepatic manifestations of HCV infection include kidney disease and diabetes mellitus, and successful treatment of HCV infection with direct-acting antivirals (DAA) may result in improvement of these comorbidities. The purpose of this study was to determine whether successful treatment of HCV infection with DAA affects immune function, renal function, and diabetes mellitus in HIV/HCV co-infected patients.
Methodology: All patients with HIV/HCV co-infection receiving care at Grady Health System_x0019_s Ponce De Leon Center from April 2013 to December 2016 were evaluated for inclusion in this retrospective cohort study. HIV mono-infected patients served as a control group. Baseline demographics evaluated include age, sex, and race. Information on past medical history and exposure to nephrotoxic agents was also collected. The primary outcome was change in CD4 cell count from baseline to 1 year after treatment of HCV infection. Other outcomes included those related to immune function, kidney function, and hyperglycemic control. In addition to CD4 cell count, immune function was also measured by CD4 percentage and CD4/CD8 ratio. In patients with CKD, kidney function was measured by serum creatinine, glomerular filtration rate, proteinuria, and hematuria. Control of diabetes was measured by hemoglobin A1c, blood glucose concentration, and antidiabetic medications.
Presentation Objective: To evaluate the effect of successful treatment of chronic HCV infection with direct-acting antivirals on immune function, renal function, and glycemic control in HIV/HCV co-infected patients.
Self-Assessment: What effect does successful treatment of chronic HCV infection with DAA have in HIV/HCV co-infected patients?
